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Nonclinical information are suggestive of the achievable potentiation of aspirin-connected fetal toxicity when combined with dipyridamole (see Details). The estimated background risk of key birth defects and miscarriage for the indicated populace is unidentified.

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Reproduction scientific studies with dipyridamole in mice, rabbits, and rats have discovered no evidence of damage towards the fetus as much as doses about 25 instances the utmost advisable each day human dose of aspirin-dipyridamole. Nonclinical info are suggestive of a attainable potentiation of aspirin-relevant fetal toxicity when coupled with dipyridamole (see Info).

Salicylate can inhibit renal clearance of methotrexate, resulting in bone marrow toxicity, especially in the aged or renal impaired.

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In ESPS2 individuals [see Medical Scientific tests], with creatinine clearances ranging from about fifteen mL/min to >100 mL/min, no improvements ended up noticed inside the pharmacokinetics of dipyridamole or its glucuronide metabolite if knowledge were corrected for discrepancies in age.

weighty Alcoholic beverages use. People that consume three or even more alcoholic beverages each day have a higher risk of bleeding during treatment method with Aggrenox, mainly because it has aspirin.

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